Kanaan Mansoor, MBBS
Cardiology Fellow
Marshall University
Huntington, West Virginia
Disclosure information not submitted.
Hisham Hirzallah, n/a
Cardiology Fellow
Department of Cardiology, Marshall University, United States
Disclosure information not submitted.
Saad ullah Malik, n/a
Resident Physician
Department of Internal Medicine, Marshall University, United States
Disclosure information not submitted.
Mohamed Suliman, n/a
Cardiology Fellow
Department of Cardiology, Marshall University, United States
Disclosure information not submitted.
Ellen Thompson
Program Director
Department of Cardiology, Marshall University, United States
Disclosure information not submitted.
Title: Association of mortality and length of stay with left ventricular GLS in septic patients
Introduction: Sepsis is a growing medical issue, and is associated with high mortality in Intensive Care Unit (ICU) patients. Septic patients are prone to left ventricular (LV) systolic dysfunction. New onset LV dysfunction is labelled as septic cardiomyopathy (SCM). SCM diagnosis is done on the basis of ejection fraction which according to previous studies has poor applicability. The speckle tracking echocardiography is a relatively newer resource for the assessment of myocardial mechanics. Left ventricular global longitudinal strain (GLS) has been reported to be associated with short term mortality in patients with sepsis. We aim to elucidate the role of GLS in septic patients as a marker for prediction of mortality, and length of stay.
Methods: This is a retrospective observational study. Patients admitted with sepsis who had an echocardiogram done during the first 48 hours of their hospital stay, were included in this study. GLS was assessed post imaging via Philips Q Lab version 13. Linear regression model was used for statistical analysis; variables adjusted for analysis included age, gender, BMI, blood pressure status, intubation status, and APACHE II score.
Results: There were a total of 106 patients included in this study, with mean age of 59.4 +/- 16.2 years. There were 59% male patients. There was no statistically significant association between GLS and mortality (p-value=0.38, R2 = 0.30). There was also no association between GLS, and length of stay in the ICU (p-value=0.89, R2 = 0.30).
Conclusion: Our study shows that there is no association of GLS with mortality or length of stay. Larger studies need to be undertaken to thoroughly understand the effect of GLS in sepsis patients.