Nafisa Wadud, MD
Resident
Orange Regional Medical Center
Middletown, NY
Disclosure information not submitted.
Naim Ahmed, DO
Resident physician
Garnet Health Medical Center
Middletown, New York, United States
Disclosure information not submitted.
Mannu Shergill, DO
Resident physician
Garnet Health Medical Center, United States
Disclosure information not submitted.
Maida Khan, MD
Resident physician
Garnet Health Medical Center, United States
Disclosure information not submitted.
Murali Krishna, MD
Physician
Garnet Health Medical Center, United States
Disclosure information not submitted.
Aamir Gilani, MD
Physician
Garnet Health Medical Center, United States
Disclosure information not submitted.
Samer El Zarif, MD
Physician
Garnet Health Medical Center, United States
Disclosure information not submitted.
Jodi Galaydick, MD
Physician
Garnet Health Medical Center, United States
Disclosure information not submitted.
Karthika Linga, MD
Physician
Garnet Health Medical Center, United States
Disclosure information not submitted.
Shravan Koor, MD
Physician
Garnet Health Medical Center, United States
Disclosure information not submitted.
Julia Galea, PharmD
Pharmacist
Garnet Health Medical Center, United States
Disclosure information not submitted.
Lauren Stuczynski, DO
Pharmacist
Garnet Health Medical Center, United States
Disclosure information not submitted.
Maria Osundele, PharmD
Pharmacist
Garnet Health Medical Center, United States
Disclosure information not submitted.
Title: Outcomes amongst intubated, non-intubated COVID-19 positive & intubated COVID-19 negative patients.
Introduction: With over three million deaths worldwide, COVID-19 is still a global pandemic, hence an urgent need for risk stratification.
Methods: retrospective study, included 245 adult patients admitted to Garnet Health Medical Center with confirmed COVID-19 results from March to May 2020. Further classified into 3 groups; intubated COVID-19 positive, intubated COVID-19 negative and non-intubated COVID-19 positive. Primary outcome for mortality, ventilator duration, ICU and length of hospital stays were compared. Statistical analysis was done by 1way ANOVA and statistical significance defined as P >0 .05.
Results: 245 patients were analyzed; 105 intubated COVID-19 positive, 115 intubated COVID-19 negative and 25 non-intubated COVID-19 positive groups. Mean age was 60.45, 63.22 and 65.96 years with male predominance 72.38%, 53.04% and 60% respectively. Caucasians seemed more affected 53.33%, 73.91% and 40% followed by African Americans. Chronic medical conditions included hypertension (63.80%, 68.69% and 84%), diabetes mellitus (44.76%, 34.78% and 48%) and asthma (13.33%, 10.43% and 8%) respectively. Mortality was 45.71% in intubated COVID-19 positive, 34.23% in intubated COVID-19 negative and 16% in non-intubated COVID-19 positive patients. COVID-19 positive patients were intubated for a mean duration of 22.14 days compared to 8.69 days in COVID-19 negative patients. Mean ICU and hospital length of stay were 16.01 and 23.7 days in intubated COVID-19 positive patients, 8.83 and 11.25 days in intubated COVID-19 negative patients, while mean ICU and hospital durations were 2.84 and 12.12 days in COVID-19 positive non-intubated patients respectively; P = 0.0001. Acute Respiratory Distress Syndrome (ARDS), in COVID-19 positive intubated patients (82.85%), acute kidney injury (AKI) (80%) with 32.38 % needing continuous renal replacement therapy (CRRT). While in COVID-19 negative intubated patients 66.95% developed AKI with 17.3 % needing CRRT and only 5.21% patients developed ARDS. COVID-19 positive non-intubated patients AKI was predominant in 64% with no CRRT and 28% developed ARDS.
Conclusions: COVID-19 positive intubated patients had greater mortality, ventilator duration, length of ICU and hospital stays. This study identified risk factors and complications that may be associated in COVID-19.