It's More Than Just Chronic Disease: Renin-Angiotensin System Alterations and Therapeutics in Critical Illness

Bonus CE Session

CE: 1.0

Bonus CE Session Moderator(s)

CD

Clifford Deutschman, MD, MS, MCCM

Vice-Chair, Research
Northwell School of Medicine and the Feinstein Institute for Medical Research
Halesite, NY

No relevant financial relationship(s) to disclose
Erin Barreto, MSc, PharmD, FCCM

Associate Professor of Pharmacy and Medicine
Mayo Clinic
Rochester, Minnesota

No relevant financial relationship(s) to disclose

This session will provide a clinical and translational update on renin-angiotensin system (RAS) dysfunction and therapeutic approaches in critically ill patients. Content will span basic science to clinical trials in this emerging area of identified psychophysiology in critical illness. Speakers will review the scientific basis of the classical and nonclassical RAS pathways, known signaling pathways, and noted RAS disturbances and their associations with outcomes in critical illness. Disease-specific sessions will cover acute respiratory distress syndrome (angiotensin-converting enzyme 2 data as therapeutic) and acute kidney injury (angiotensin 2 data), covering therapeutic (at times opposing) approaches to manipulate the RAS in critical illness.

Learning Objectives:

Describe renin-angiotensin system (RAS) disturbances in critical illness at systemic and local levels and their pathophysiologic consequences
Describe the pathophysiology of RAS disruption in acute respiratory distress syndrome and evaluate therapeutics, notably angiotensin-converting enzyme 2, for current and future use
Describe the pathophysiology of RAS disruption in acute kidney injury and evaluate therapeutics, notably angiotensin 2, for current and future use

Presentations:

Renin-Angiotensin System Complexities and Disturbances in Critical Illness
Bonus CE Session Faculty: Alexander Flannery, PharmD, PhD, BCCCP – University of Kentucky College of Pharmacy
Renin-Angiotensin System Dysregulation in Acute Respiratory Distress Syndrome
Bonus CE Session Faculty: Akram Khan – Oregon Health and Sciences University
Renin-Angiotensin System Disturbances in Acute Kidney Injury
Bonus CE Session Faculty: Daniel Leisman, MD, MSCR – Massachusetts General Hospital