Stroke Volume Change Predicts Patient Outcome

Research Presenters(s)

• 

  Heath Latham, MD

  Professor of Medicine
  University of Kansas Health System
  Kansas City, Kansas

  Disclosure information not submitted.

  Slides and Audio

First Author(s)

• 

  Muhammad Javed, MD, FCCP, FCCM,FCCM

  Associate Program Director
  Mercy Hospital Saint Louis
  Saint Louis, Missouri, United States

  Disclosure information not submitted.

Co-Author(s)

• 

  Douglas Hansell, MD, MPH

  Associate Professor
  Massachusetts
  Boston, Massachusetts, United States

  Disclosure information not submitted.
• 

  Jennifer Sahatjian

  Baxter Healthcare

  Disclosure information not submitted.

Title: Stroke Volume Change Predicts Patient Outcome

Introduction:  Cardiac function is known to be negatively impacted by sepsis. Monitoring Cardiac Output (CO) and Stroke volume (SV) trends over the course of treatment may provide insight into cardiac function and may be used to predict patient outcome. The goal of this study was to explore the relationship between the change in stroke volume and outcome in critically ill patients.

Methods:  The Starling Registry study is an observational registry study evaluating trends in CO and SV over time as related to patient outcome (NCT04648293). Patients that exhibited an overall improvement in SV (first SV measurement compared to last SV measurement) were compared to those who did not exhibit improvement.

Results:  127 critical care patients received hemodynamic monitoring during their ICU stay across two different hospitals. 51 % were female, and the average age was 64 years. 64% of the patients had sepsis, and 15% of patients were positive for COVID. The average time between first and last SV measurement was approximately 7 hours. Notably, patients who exhibited an overall improvement in SV exhibited a decrease in mortality (14.9%) compared to those who did not improve (35.0%, p=0.018)

Conclusions:  We have previously shown that patients who show an improvement in SV in response to the resuscitation exhibited improved outcome. Trending cardiac output over a 1-3 day monitoring period revealed additional usefulness in predicting patients with improved outcome. These results highlight the importance of trending hemodynamics in therapy.