Pavan Bhatraju, MD, MS
Assistant Professor, Pulmonary, Critical Care
University of Washington Medical Center
Seattle
Disclosure information not submitted.
Avantika Srivastava, MS
Statistician
University of Pittsburgh, United States
Disclosure information not submitted.
George Anesi, MD
Assistant Professor of Medicine, University of Pennsylvania
University of Pennsylvania
Philadelphia, Pennsylvania
Disclosure information not submitted.
Radu Postelnicu, MD
Assistant Professor
NYU Langone Medical Center and School of Medicine, United States
Disclosure information not submitted.
Adair Andrews, RN, MATD
Staff
Society of Critical Care Medicine, United States
Disclosure information not submitted.
Martin Gonzalez, MS
Staff
Society of Critical Care Medicine, United States
Disclosure information not submitted.
Christopher Kratochvil, MD
Professor
University of Nebraska Medical Center, Nebraska, United States
Disclosure information not submitted.
Vishakha Kumar, MD, MBA
Society of Critical Care Medicine
Mount Prospect, Illinois
Disclosure information not submitted.
David Wyles, MD
Professor
University of Colorado, United States
Disclosure information not submitted.
Richard Lee, MD
Assistant Professor
University of California Irvine, United States
Disclosure information not submitted.
Karen Lutrick, PhD
Assistant Professor
University of Arizona, United States
Disclosure information not submitted.
David Brett-Major, MD, MPH
Professor
University Of Nebraska Medical Center, United States
Disclosure information not submitted.
Vikramjit Mukherjee, MD
Assistant Professor
NYU School of Medicine, United States
Disclosure information not submitted.
Leopoldo Segal, MD
Assistant Professor
NYU Langone Medical Center and School of Medicine, United States
Disclosure information not submitted.
Jonathan Sevransky, MD, MHS,FCCM
Professor
Emory University Hospital
Atlanta, Georgia
Disclosure information not submitted.
Mark Wurfel, MD, PhD
Professor
University of Washington School of Medicine, United States
Disclosure information not submitted.
Douglas Landsittel, PhD
Professor
University of Pittsburgh Swanson School of Engineering, United States
Disclosure information not submitted.
J. Perren Cobb, MD, FACS,FCCM
Professor and Clinical Scholar
Keck Medical Center of USC
Los Angeles
Disclosure information not submitted.
Laura Evans, MD, MS, MSc, FCCM
Medical Director of Critical Care
University of Washington Medical Center
Seattle
Disclosure information not submitted.
Title: Severe Acute Respiratory Infection – Preparedness (SARI-PREP): A Multicenter Prospective Study
Objectives: We designed a prospective cohort study to systematically study patients with severe acute respiratory infection (SARI) and improve hospital preparedness (SARI-PREP). The goal of this project is to evaluate the natural history, prognostic biomarkers, and characteristics, including hospital stress, associated with SARI clinical outcomes and severity.
Methods: In collaboration with the Society of Critical Care Medicine Discovery Research Network and the National Emerging Special Pathogen Training and Education Center (NETEC), SARI-PREP is an ongoing, prospective, observational, multi-center cohort study of hospitalized patients with respiratory viral infections. We collected patient demographics, signs, symptoms, and medications; microbiology, imaging, and other diagnostics; mechanical ventilation, hospital procedures, and other interventions; and clinical outcomes. Hospital leadership completed a weekly hospital stress survey. Respiratory, blood, and urine biospecimens were collected from patients on days 0, 3, 7-14 after study enrollment and at hospital discharge.
Measurements and Main
Results: SARI-PREP enrollment began on April 4, 2020 and currently includes 674 patients. Here we report results from the first 400 patients: 216 are from the University of Washington Hospitals, Seattle WA, 142 from New York University, New York NY and 42 from University of Southern California, Los Angeles, CA. Almost all tested positive for SARS-CoV-2 infection (n=397), whereas 3 patients tested positive for an alternative viral pathogen. The mean (±SD) age of the patients was 57±16 years; 72% were men, 62% were White, 14% were Asian, 12% were Black, and 31% were Hispanic. Most of the patients were admitted to the intensive care unit (96%). The median (interquartile range) hospital length of stay was 22 (9-46) days. Rates of invasive mechanical ventilation (72%) and renal replacement therapy (19%) were common and the rate of hospital mortality was 35%.
Conclusions: Initial SARI-PREP analysis indicates enrollment of a diverse population of hospitalized patients primarily with SARS-CoV-2 infection. The demographics and clinical outcomes of our cohort mirror other large critically ill cohorts of COVID-19 patients. Results of a concomitant, weekly, hospital stress assessment are reported separately.