Mayank Sharma, MBBS
Research Fellow
n/a, Minnesota, United States
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Vikas Bansal, MPH, MBBS
Research Fellow
Mayo Clinic
Rochester, Minnesota
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Marija Bogojevic, MD,
Resident Physician
Montefiore New Rochelle Hospital, Minnesota, United States
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Romil Singh, MD
Resident
n/a
Rochester, Minnesota, United States
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Allison LeMahieu, BS, MS
Biostatistician
Mayo Clinic
Rochester, Minnesota, United States
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Abigail La Nou, MD
Medical Doctor
Mayo Clinic Health System in Eau Claire, United States
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Andrew Hanson, MS
Biostatistician
Mayo Clinic
Rochester, Minnesota, United States
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Phillip Schulte, MD
Senior Associate Consultant II
n/a
Rochester, Minnesota, United States
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Neha Deo, BS
Medical Student
Mayo Clinic Alix School of Medicine
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Simon Zec, MD (he/him/his)
Research Fellow, Pulmonary and Critical Care Medicine
Mayo Clinic
Rochester, Minnesota, United States
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Vishakha Kumar, MD, MBA
Society of Critical Care Medicine
Mount Prospect, Illinois
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Allan Walkey, MD (he/him/his)
Professor of Medicine
Boston University
Boston, Massachusetts, United States
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Andres Acosta, MD Ph.D, n/a
Gastroenterologist
Mayo Clinic, United States
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Ognjen Gajic, MD
Professor
Mayo Clinic
Rochester, Minnesota, United States
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Rahul Kashyap, MD, MBA,
Medical Director Research
Wellspan Health-York Hospital
York, Pennsylvania
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Juan Pablo Domecq Garces, MD
Assistant Professor of Medicine
Mayo Clinic College of Medicine
North Mankato, Minnesota, United States
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Title:
Association Between GI Symptoms and Covid-19: Results from the SCMM Discovery Virus Registry
Introduction:
Gastrointestinal symptoms are common is patients with COVID-19. However, there is mixed evidence on disease severity and hospital outcomes in COVID-19 patients presenting with gastrointestinal symptoms.
Methods:
This is a prospective, multicenter, observational, international registry including 306 hospitals in 28 countries within the Society of Critical Care Medicine Discovery VIRUS: COVID-19 Registry. All hospitalized, symptomatic, adult (≥18 years old) COVID-19 patients enrolled in the registry were included in this study. Patient’s demographics and hospital outcomes (disease severity, ICU admission and mortality) were compared among patient with (i) Non-gastrointestinal symptoms (ii) Isolated gastrointestinal symptoms and (iii) Gastrointestinal symptoms and other non-gastrointestinal symptoms. Adjustment variables included age, gender, admission date in quarter year since March 2020, pre-hospital medications and comorbidities.
Results:
A total of 21,453 patients were included in the analyses; 9,494 (44%) reported gastrointestinal symptoms. There were significant differences in baseline demographics, and signs and symptoms and comorbidities at hospital admission between patients with and without gastrointestinal symptoms. Nausea or vomiting were the most frequent upper gastrointestinal symptoms and diarrhea was the most frequent lower gastrointestinal symptom. Patients with isolated gastrointestinal symptoms had lower odds of ICU mortality (AOR: 0.59, 95% CI: 0.39 – 0.88) and hospital mortality (AOR: 0.60, 95% CI: 0.51 – 0.70) in comparison to patients with non-gastrointestinal symptoms. Patients with combined gastrointestinal and non-gastrointestinal symptoms had lower odds of hospital mortality (AOR: 0.78, 95% CI: 0.72 – 0.85).
Conclusions:
Using a large multinational registry we found that GI symptoms are commonly reported in patients with COVID-19. Upon hospitalization, patients presenting with gastrointestinal symptoms (isolated or along with other non-gastrointestinal symptoms), may have a better prognosis than patients with non-gastrointestinal symptoms.